Carbon disulfide is a volatile organic solvent that is used industrially as a starting material in rayon manufacture in the viscose process. It was important historically in the cold vulcanization of rubber. Although no longer used in this form, carbon disulfide is still a major industrial precursor in rubber industry chemical synthesis and has a number of other industrial applications. Carbon disulfide also is widely used as a solvent in a variety of laboratory settings. It is a metabolite of the drug disulfiram (See Disulfiram) and a spontaneous breakdown by-product of the pesticide metam sodium.

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   Mechanism of toxicity. Carbon disulfide toxicity appears to involve disruption of a number of metabolic pathways in various organ systems, including but not limited to the CNS. Although key toxic effects have been attributed to the functional disruption of enzymes, especially in dopamine-dependent systems, carbon disulfide is widely reactive with a variety of biologic substrates.

   
   
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   Toxic dose

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