Geriatric Medicine

Association Between Serum Cathepsin S and Mortality in Older Adults

Jobs E, Ingelsson E, Risérus U, et al (Uppsala Univ, Sweden) JAMA 306:1113-1121, 2011^§

Abstract

Context

Experimental data suggest that cathepsin S, a cysteine protease, is involved in the complex pathways leading to cardiovascular disease and cancer. However, prospective data concerning a potential association between circulating cathepsin S levels and mortality are lacking.

Objective

To investigate associations between circulating cathepsin S levels and mortality in 2 independent cohorts of elderly men and women.

Design, Setting, and Participants

Prospective study using 2 community-based cohorts, the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1009; mean age: 71 years; baseline period: 1991-1995; median follow-up: 12.6 years; end of follow-up: 2006) and the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 987; 50% women; mean age: 70 years; baseline period: 2001-2004; median follow-up: 7.9 years; end of follow-up: 2010). Serum samples were used to measure cathepsin S.

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