between brain interstitial and systemic glucose concentrations after subarachnoid hemorrhage

Critical Care Medicine


Adult Critical Care


Relation between brain interstitial and systemic glucose concentrations after subarachnoid hemorrhage


Zetterling M, Hillered L, Enblad P, et al (Uppsala Univ, Sweden) J Neurosurg 115:66-74, 2011§



M. Mathru, MD



Evidence Ranking


• B



Expert Rating


• 2



Abstract






Conclusions


After SAH, there was a positive correlation between plasma and MD glucose concentrations with a high degree of individual variation. A gradual decline in MD glucose and the MD/plasma glucose ratio and an increase in MD pyruvate and MD lactate concentrations during the 1st week after SAH suggest a transition to a hyperglycolytic state with increased cerebral glucose consumption. The administration of insulin was related to a lowering of MD glucose and MD pyruvate, often to low levels even though plasma glucose values remained above 6 mmol/L. After SAH, the administration of insulin could impede the glucose supply of the brain (Figs 2 and 3).


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Jan 28, 2017 | Posted by in ANESTHESIA | Comments Off on between brain interstitial and systemic glucose concentrations after subarachnoid hemorrhage

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