Be Cautious in Using Ketorolac in Patients with Marginal Urine Output or Renal Function



Be Cautious in Using Ketorolac in Patients with Marginal Urine Output or Renal Function


Angela D. Shoher MD



Ketorolac is a nonsteroidal inflammatory agent with greater systemic analgesic properties than anti-inflammatory activity. The onset and efficacy of its analgesic properties are claimed to be comparable with those of morphine. Ketorolac works by competitively inhibiting the cyclooxygenase isoenzymes (COX-1 and COX-2). These enzymes catalyze the conversion of arachidonic acid to prostaglandins. Prostaglandins E and F appear to be responsible for sensitizing pain receptors, explaining the analgesic properties of the drug. Bioavailability of the drug is 100% after oral, intravenous, or intramuscular administration. Food only decreases the rate but not the extent of absorption. Ketorolac is also 99% bound to albumin. It is metabolized by the liver to a form that is less than 1% as potent as the original form.

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Jul 1, 2016 | Posted by in ANESTHESIA | Comments Off on Be Cautious in Using Ketorolac in Patients with Marginal Urine Output or Renal Function
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