Phenothiazines, butyrophenones, and other related drugs are used widely to treat psychosis and agitated depression. In addition, some of these drugs (eg, prochlorperazine, promethazine, and droperidol) are used as antiemetic agents. Suicidal overdoses are common, but because of the high toxic-therapeutic ratio, acute overdose seldom results in death. A large number of newer agents that often are referred to as “atypical antipsychotics” have been developed. Atypical antipsychotics differ from other neuroleptics in their binding to dopamine receptors and their effects on dopamine-mediated behaviors. Overdose experience with these agents is limited. Table II–11 describes available antipsychotic agents.