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This chapter will review the practice guideline on anaphylaxis by the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology.
Anaphylaxis is an acute multiorgan dysfunction syndrome that may be potentially fatal if not treated promptly.
Signs and symptoms ( table 19.1 )
Signs and Symptoms of Anaphylaxis a
Adapted from Lieberman P, Nicklas RA, Randolph C, et al. Anaphylaxis—a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115:341–384 and Simons FER. Anaphylaxis. J Allergy Clin Immunol. 2010;125:S161–S181.
Skin and mucosal tissue (most frequent)
Hives, pruritis, flushing
Nasal discharge or congestion
Upper airway angioedema
Strider, shortness of breath, wheeze, cough, or bronchospasm
Nausea, vomiting, and/or diarrhea
Central nervous system (least frequent)
Feeling of impending doom
Triggers of Anaphylaxis
Adapted from Simons FER. Anaphylaxis. J Allergy Clin Immunol. 2010;125:S161–S181.
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