This chapter will review the practice guideline on anaphylaxis by the American Academy of Allergy, Asthma, and Immunology and the American College of Allergy, Asthma, and Immunology.


Anaphylaxis is an acute multiorgan dysfunction syndrome that may be potentially fatal if not treated promptly.

Signs and symptoms ( table 19.1 )

Table 19.1

Signs and Symptoms of Anaphylaxis a

Adapted from Lieberman P, Nicklas RA, Randolph C, et al. Anaphylaxis—a practice parameter update 2015. Ann Allergy Asthma Immunol. 2015;115:341–384 and Simons FER. Anaphylaxis. J Allergy Clin Immunol. 2010;125:S161–S181.

  • Skin and mucosal tissue (most frequent)

    • Hives, pruritis, flushing

    • Angioedema

  • Respiratory

    • Nasal discharge or congestion

    • Upper airway angioedema

    • Strider, shortness of breath, wheeze, cough, or bronchospasm

  • Cardiovascular

    • Tachycardia

    • Hypotension

    • Dizziness

    • Syncope

  • Gastrointestinal

    • Nausea, vomiting, and/or diarrhea

    • Abdominal cramps

  • Central nervous system (least frequent)

    • Headache

    • Seizure

    • Feeling of impending doom

a Signs and symptoms listed in order of frequency

Triggers ( table 19.2 )

Feb 28, 2021 | Posted by in EMERGENCY MEDICINE | Comments Off on Anaphylaxis

Full access? Get Clinical Tree

Get Clinical Tree app for offline access