Agent |
Dosage |
Time Prior to Exposure |
|---|
Prednisone or Hydrocortisone |
50 mg PO
100 mg IV |
13 h, 7 h, and 1 h prior to exposure |
Diphenhydramine |
50 mg PO or IV |
13 h, 7 h, and 1 h prior to exposure |
H2-blockerb |
See below |
13 h and 1 h prior to exposure |
Ephedrine (optional) |
25 mg PO |
1 h prior to exposure |
IV, intravenous; PO, by mouth
Note: Consider for patients with prior history of dye reaction; may also consider use of nonionic contrast material |
aThis regimen also appropriate for other prophylactic situations.
bRanitidine: 150 mg PO or 50 mg IV
Famotidine: 20 mg PO/IV
Cimetidine: 300 mg PO/IV |
