Abstract
Background
Hip surgeries are one of the common orthopedic surgeries, especially in the geriatricnpopulation following trauma, postoperative pain control and early ambulation are the main concerns for decreasing hospital stay and postoperative complications. We aimed to analyze the ultrasound-guided pericapsular nerve group block (PENG) effect versus fascia iliaca compartment block (FICB) on the time needed for unaided mobilization and postoperative analgesics consumption in hip arthroplasty.
Methods
The study was a randomized, prospective, comparative study carried out at Ain Shams University Hospital where 44 patients subjected to hip arthroplasty were randomized into two equal groups; Group (F) in which patients received FICB under ultrasound guidance and Group (P) in which patients received PENG under ultrasound guidance. Both blocks were performed by injecting 20 mL of 0.25 % bupivacaine immediately after spinal anesthesia. The time needed for unaided mobilization was assessed by the time up and go test (TUG) and postoperative pain was assessed by visual analogue scale (VAS) in the first 24 h postoperatively.
Results
Regarding ambulation data over the first 24 h following surgery, the time needed for unaided mobilization was significantly shorter in the PENG group than FICB group. No statistically significant differences were determined between both groups as regards postoperative complications, total narcotic consumption, and VAS score. Conclusions: The Pericapsular nerve group (PENG) block demonstrated earlier unaided ambulation and delayed first rescue analgesia in hip arthroplasty compared to those who were administered Facia iliaca compartment blocks)FICB(in hip arthroplasty. Both blocks offered efficient postoperative pain control without difference in total opioid requirements.
1
Introduction
The hip joint, which is supplied by nerve fibers from the femoral nerve (FN), obturator nerve, and accessory obturator nerve, is remarkably sensitive. Among deep somatic structures, it has the lowest pain threshold; therefore, hip fractures are among the most excruciatingly painful and require effective pain management to alleviate discomfort during surgical preparation, transportation, or immobilization. Patients afflicted with hip or femur fractures can obtain effective perioperative analgesia through the low-cost and simple-to-execute fascia iliaca compartment block (FICB). In recent case reports, it has been suggested that Pericapsular Nerve Group Block (PENG) may serve as a viable alternative technique for managing post-operative pain following hip surgeries. This is attributed to the fact that PENG inhibits the innervating articular branches of the obturator nerve, accessory obturator nerve, and FN, all of which supply nerves to the anterior hip capsule. Furthermore, PENG does not induce weakness in the lower extremities, which could impede patients’ early mobilization.
We aimed to analyze the effect of ultrasound-guided PENG versus FICB on the time needed for unaided mobilization and postoperative analgesics consumption in hip arthroplasty.
2
Methods
This study was conducted on 44 patients, following approval from our institute’s Ethical Committee of Scientific Research at the Faculty of Medicine, Ain Shams University Hospital, Cairo, Egypt (FAMSU MD 271/2022). It was registered with the Pan African registry (registration No PACTR202307810865219). It followed the Consolidated Standards of Reporting Trials (CONSORT) statement and was done in compliance with the Declaration of Helsinki-2013, with each patient providing written valid consent prior to participation. Patients included ranging in age from 21 to 70 and Physical Status I, II in accordance with the American Society of Anesthesiologists (ASA) score undergoing elective unilateral hip arthroplasty under spinal anesthesia.
We excluded patients who refused to join in the study or declined to receive spinal anesthesia, patients that required additional analgesia or other type of anesthesia (general anesthesia) during the procedure, patients with multiple fractures, spine deformities, nearby infections, coagulation disorders, mental illness history, drug addiction history, or allergies to medications utilized in the investigation.
We randomly sorted participants into two comparable groups of 22 patients utilizing a table of computer-generated random numbers developed by a statistical analyst who was unaware of the study. Patients in (F group) received ultrasound-guided FICB immediately after spinal anesthesia, whereas those in the (P group) received ultrasound-guided PENG immediately following spinal anesthesia. A senior anesthesia professor in our department, who was certified by our department chairman as an instructor, performed both blocks. Data was collected by another anesthesiologist who was not included or interested in the study
2.1
Sample size
Based on an examination of prior study findings indicating that participants who underwent total hip arthroplasty and underwent ultrasound-guided PENG had a shorter mean of first walking time postoperatively than those who underwent supra-inguinal FICB (19.6 (9.6) versus 26.5 (8.2), respectively), a minimum sample size of 44 patients was established utilizing power evaluation and sample size tools (PASS11) (version11.0.08) to estimate the sample size. Power was set at 80 %, and an alpha error of 5 % was used.
2.2
Study procedure
All patients underwent comprehensive clinical assessment prior to the procedure and were educated on the visual analogue scale (VAS), where 10 denotes the worst pain and 0 denotes no pain.
An intravenous line was inserted upon arrival to the operating room, a 10 ml/kg preload of lactated Ringer solution was administered within 30 min prior to the procedure, and 50 micrograms of fentanyl were administered intravenously for pain relief. All candidates were monitored by pulse oximetry, electrocardiography, non-invasive blood pressure, and urine output.
Spinal anesthesia was conducted under a completely sterile technique via the L3-L4 or L4-L5 intervertebral space with a 25-gauge Quincke needle and an intrathecal injection of 12.5–15 mg heavy bupivacaine in combination with 25 micrograms of fentanyl. Supplemental oxygen 2 L/Min was conducted on all candidates via nasal prongs. Assessment of the level of spinal anesthesia besides baseline hemodynamics was recorded. In case of failure of spinal anesthesia general anesthesia were given and the patient was subsequently excluded from the study.
The research included forty-four participants who met the specified inclusion criteria. Utilizing a table of computer-generated random numbers, they were categorized into two comparable groups of twenty-two patients each: group F and group P.
Group F: The patients underwent ultrasound-guided Facia Iliaca Compartment Block under strict aseptic conditions following spinal anesthesia. The procedure was performed with an ultrasound device equipped with a linear probe (8–13 MHz) manufactured by SonoSiteTM, Inc., Bothell, WA 98,021, USA. The probe was positioned transversely along the thigh, 1/3 of the total distance between the pubic tubercle and anterior superior iliac spine. An echogenic needle measuring 4 inches and 22 gauge (PAJUNK, SonoPlex STIM REF 001,185–71) was introduced in plane while the needle tip was observed penetrating the fascia lata and fascia iliaca with two distinct popping sensations. A 20 mL amount of 0.25 percent bupivacaine was injected, taking into account not to exceed the toxic dose of bupivacaine (2.5 mg/kg), following negative aspiration and ultrasound imaging of drug solution distribution in tissue planes.
Group P: The patients underwent ultrasound-guided Pericapsular Nerve Group block under strict aseptic conditions following spinal anesthesia. The procedure was performed utilizing the identical ultrasound device, which featured a linear probe positioned on the thigh in alignment with a line just below and parallel to the inguinal ligament. In order to locate the psoas tendon, the ilio-pubic eminence, and the anterior inferior iliac spine, the probe was subsequently rotated 45° An identical echogenic needle, measuring 4 inches in length and 22 gauge, was introduced into the musculofascial plane posterior to the pubic ramus and anterior to the psoas tendon. The tip of the needle was positioned in this plane. A 20 mL amount of 0.25 percent bupivacaine was injected, taking into account not to exceed the toxic dose of bupivacaine (2.5 mg/kg), following negative aspiration and ultrasound imaging of drug solution distribution in tissue planes.
All candidates were moved to the Post-Anaesthesia Care Unit after the procedure, where they were closely observed for HR, blood pressure, and oxygen saturation (Spo2) for 2 h then transferred to ward and received 1 g of paracetamol every 8 h as a postoperative analgesic standard medication.
The primary outcome of our study was the time needed for unaided mobilization of the patient utilizing the timed up and go test (TUG) that calculates the time taken to stand up from a chair, move 3 m, return to the chair and sit down unaided in seconds.
The secondary outcomes were:
- 1.
The intensity of pain following surgery was assessed by Visual analogue score (VAS) in PACU and ward at the following time intervals postoperatively 1/2, 2, 4, 8, 12, 24 hrs and if the VAS was >3, the patient received 5 mg nalbuphine intravenously as rescue analgesia to be repeated within 20 min till VAS ≤ 3.
- 2.
The patient’s overall postoperative rescue analgesic dosage.
- 3.
Time till the first dose of rescue analgesia needed by the patient.
- 4.
The postoperative anesthetic complications related to the anesthetic procedure, such as hematoma at the site of injection, nausea, vomiting, and hypotension, for 24 h.
2.3
Statical analysis
Number and frequency were used to describe the qualitative data, whereas mean ± standard deviation (SD) was used to provide the quantitative data. The tests used were an independent-sample t -test, chi-square (X2) test, and Whitney U test.
The error margin accepted was established at 5 %, and the confidence interval of 95 % was chosen. Thus, if the p-value was <0.05, it was considered significant.
3
Results
The trial flow diagram shown in [ Fig. 1 ] demonstrated that out of 51 patients; three individuals did not meet the criteria of inclusion, four individuals refused to participate in our study, leaving 44 patients suitable to be enrolled in our trial.


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